Exploring the causes of congenital heart disease
Our long-term goal is to help eradicate Congenital Heart Disease (CHD) through better understanding of the mechanism(s) involved in its pathogenesis. The causes of CHD are likely multiple and often genetic in nature; for many though, the etiology remains unknown. Our hypothesis is that perinatal infection during cardiac morphogenesis induces CHD. We are conducting studies to test this hypothesis both by analysis of specimens from woman with pregnancies affected by CHD, as well as by studying offspring in animal models exposed to infections in early gestation.